PRDM16, Negatively Regulated by miR-372-3p, Suppresses Cell Proliferation and Invasion in Prostate Cancer

Prostate cancer (PCa) is one of the most prevalent malignant tumors. The alternation microRNA (miRNA) expression associated with prostate progression, whereas its way to influence progression remains elusive. levels PRDM16 mRNA and miR-372-3p in PCa cell lines were analyzed using qRT-PCR. protein was also western blot. CCK-8, wound healing, Transwell assays applied examine proliferation, migration, invasion cells, respectively. Dual-luciferase reporter assay utilized validate interaction between PRDM16. In present study, markedly decreased observed cells. overexpression hampered cellular invasion, while silencing had opposite effect. Moreover, could target regulation Rescue experiments demonstrated that upregulating conspicuously restored inhibitory effect increased on PCa. Overall, our study clarifies biological role miR-372-3p/PRDM16 axis which may be effective biomarkers for clinical treatment cancer.